Disinfection By-Products of para-Hydroxybenzoate Esters (Parabens): Synthesis and Mass Spectrometric Study

Discovery of a marine bacterium producing 4-hydroxybenzoate and its alkyl esters, parabens.

Chemically synthesized 4-hydroxybenzoate (4HBA) is widely used in the chemical and electrical industries as a material for producing polymers such as those of the liquid crystal type. Its alkyl esters, called parabens, have been the most widely used preservatives by the food and cosmetic industries. We report here for the first time a microorganism, a marine bacterium, which biosynthesizes thes...

A mass spectrometric technique for detecting and identifying by-products in the synthesis of peptides.

The utility of a new mass spectrometric technique for detecting and identifying peptide by-products produced in the synthesis of peptides is demonstrated. The technique involves three sequential steps: (1) practically nondestructive 252Cf plasma desorption mass spectrometric analysis of monolayer amounts of the peptide(s) of interest bound to a thin layer of nitrocellulose; (2) enzyme-catalyzed...

NTP taps disinfection by-products for study.

The use of chlorination to purify water supplies is considered one of the most important public health advances of the twentieth century. Following the 1908 introduction of widespread water chlorination, once-common diseases such as cholera, dysentery, and typhoid fever were practically eliminated. However, the chlorination cure-all proved to have a caveat: disinfection by-products (DBPs), whic...

Simultaneous Determination of Disinfection By-products in Water Samples from Advanced Membrane Treatments by Headspace Solid Phase Microextraction and Gas Chromatography-Mass Spectrometry

A headspace-solid phase microextraction (HS-SPME) and gas chromatography-mass spectrometry (GC-MS) method has been developed for the simultaneously determination of 20 disinfection by-products (DBPs) in water samples from reverse osmosis (RO) membranes. Selected compounds belong to different families including: trihalomethanes (THMs), halogenated acetonitriles (HANs), halogenated nitromethanes ...

Synthesis and mass spectrometric structural chracterization of ubiquitin conjugates